Jag1^tm1Jlew
Targeted Allele Detail

Summary

• Symbol: Jag1^tm1Jlew
• Name: jagged 1; targeted mutation 1, Julian Lewis
• MGI ID: MGI:3623344
• Synonyms: Jag1^flox
• Gene: Jag1 Location: Chr2:136923371-136958440 bp, - strand
• Alliance: Jag1^tm1Jlew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107414
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons encoding the DSL (Delta-Serrate-Lag2) domain required for binding to Notch. Expression of cre recombinase is expected to knock out gene function by removing exons 4 and 5 (the DSL encoding exons) and causing a frame shift that generates a stop codon after the start of exon 6. (J:107414)

Expression

In Mice Carrying this Mutation:	42 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jag1 Mutation: 78 strains or lines available

References

• Original: J:107414 Brooker R, et al., Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development. 2006 Apr;133(7):1277-86
• All: 31 reference(s)