Zfp148^tm1Djl
Targeted Allele Detail

Summary

• Symbol: Zfp148^tm1Djl
• Name: zinc finger protein 148; targeted mutation 1, David J Law
• MGI ID: MGI:3623378
• Synonyms: ZBP-89^deltaN
• Gene: Zfp148 Location: Chr16:33201145-33324273 bp, + strand Genetic Position: Chr16, 23.93 cM
• Alliance: Zfp148^tm1Djl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107441
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was used to replace exon 4 with a PGK-neo cassette with a transcriptional stop codon. Exon 4 sequences were not expressed in mutants, however, both upstream and downstream exons were expressed. RT-PCR and sequencing showed that exon 3 was spliced directly to exon 5, excluding the intervening neo cassette. (J:107441)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp148 Mutation: 112 strains or lines available

References

• Original: J:107441 Law DJ, et al., An isoform of ZBP-89 predisposes the colon to colitis. Nucleic Acids Res. 2006;34(5):1342-50
• All: 1 reference(s)