Lcp2^tm2Gak
Targeted Allele Detail

Summary

• Symbol: Lcp2^tm2Gak
• Name: lymphocyte cytosolic protein 2; targeted mutation 2, Gary A Koretzky
• MGI ID: MGI:3623388
• Synonyms: Slp-76^2lox, Slp-76 cKO, Slp-76^F, Slp-76^fl
• Gene: Lcp2 Location: Chr11:33996928-34042281 bp, + strand Genetic Position: Chr11, 19.43 cM
• Alliance: Lcp2^tm2Gak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107467
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 3 with loxP sites. Aberrant splicing of exon 2 to exon 4 or 5 results in a frameshift, creating a premature stop codon. (J:107467)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lcp2 Mutation: 41 strains or lines available

References

• Original: J:107467 Maltzman JS, et al., Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection. J Exp Med. 2005 Oct 3;202(7):893-900
• All: 19 reference(s)