Ossc3^CBA/Ca
QTL Variant Detail

Summary

• QTL variant: Ossc3^CBA/Ca
• Name: osteosarcoma susceptibility 3; CBA/Ca
• MGI ID: MGI:3623401
• QTL: Ossc3 Location: Chr14:87863768-87863926 bp Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: CBA/Ca

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: Animals heterozygous for BALB/c and CBA/Ca alleles exhibit increased incidence of alpha particle-induced osteosarcoma and decreased mean latency time. (J:107725)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:107725

BALB/c and CBA/Ca inbreds, and their F1 and backcross progeny were informative in mapping alpha particle induced osteosarcoma in mice. 169 (BALB/c x (BALB/c x CBA/Ca) backcross progeny and 53 polymorphic markers spaced, on average, 18 cM apart were used in QTL mapping. Parental strain BALB/c exhibits increased osteosarcoma incidence and decreased mean latency time compared to parental strain CBA/Ca.

Ossc2, a locus identified in this study was previously mapped to mouse Chromosome 14 in Rosemann M et al., "Bone tumorigenesis inducedby alpha-particle radiation: mapping of genetic Loci influencing predisposition in mice." Radiat Res 2002 Apr;157(4):426-34. Only the Ossc2 locus was significant, LOD=3.31, peaking at marker D14Mit125. The 95% confidence interval of Ossc2 spans 2.9 cM - 33.7 cM.

07.22.2015 Curator Note: Because Ossc2 was orginally mapped in the publication noted above using a T Stock x (C3H/HeJ x 102/El)F1 population, which differs from the cross used here, we consider the current map study a separate mapping experiment and have named this QTL Ossc3.

Four additional suggestive loci were mapped: one to Chr 4 with a peak at D4Mit172; another mapped to Chr 5 with a peak at D5Mit24, another mapped to Chr 12 with a peak at D12Mit157, and another to Chr 18 peaking at D18Mit119. Thesuggestive loci all added to increased tumor susceptibility and modified the effect to Ossc3.

Heterozygosity for BALB/c- and CBA/Ca-derived alleles at Ossc3 (chr14) and D18Mit119 (chr18) confer increased susceptibility to alpha particle induced osteocarsoma.

Homozygosity for BALB/c-derived alleles at D4Mit172 (chr4), D5Mit24 (chr5), and D12Mit157 (chr12) enhanced susceptibility to alpha particle induced osteosarcoma.

Backcross animals inheriting susceptibility alleles at all 5 mapped loci exhibit the highest osteosarcoma incidence and the shortest latency time.

References

• Original: J:107725 Rosemann M, et al., Multilocus inheritance determines predisposition to alpha-radiation induced bone tumourigenesis in mice. Int J Cancer. 2006 May 1;118(9):2132-8
• All: 1 reference(s)