Crlf2^tm1Wjl
Targeted Allele Detail

Summary

• Symbol: Crlf2^tm1Wjl
• Name: cytokine receptor-like factor 2; targeted mutation 1, Warren J Leonard
• MGI ID: MGI:3623417
• Synonyms: Tslpr^-, TSLPR^-
• Gene: Crlf2 Location: Chr5:109702575-109706859 bp, - strand Genetic Position: Chr5, 53.24 cM
• Alliance: Crlf2^tm1Wjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108209
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to delete all exons of the locus and replace them with a neomycin resistance gene. The inactivation of the gene was confirmed by the defective response of mutant splenocytes compared with wild-type to treatment with anti-CD3 plus TSLP versus anti-CD3 alone. (J:108209)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crlf2 Mutation: 21 strains or lines available

References

• Original: J:108209 Al-Shami A, et al., A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med. 2004 Jul 19;200(2):159-68
• All: 39 reference(s)