Cdkn1b^tm2Mlf
Targeted Allele Detail

Summary

• Symbol: Cdkn1b^tm2Mlf
• Name: cyclin dependent kinase inhibitor 1B; targeted mutation 2, Matthew L Fero
• MGI ID: MGI:3623439
• Synonyms: p27^L+, p27loxP
• Gene: Cdkn1b Location: Chr6:134897364-134902476 bp, + strand Genetic Position: Chr6, 65.77 cM
• Alliance: Cdkn1b^tm2Mlf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107588
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank the locus. An FRT-flanked neo included in the vector was subsequently removed via flp mediated recombination. Protein was detected in mutants, but in moderately decreased amounts. (J:107588)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn1b Mutation: 26 strains or lines available

References

• Original: J:107588 Chien WM, et al., Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4122-7
• All: 10 reference(s)