Cdkn1b^tm3Mlf
Targeted Allele Detail

Summary

• Symbol: Cdkn1b^tm3Mlf
• Name: cyclin dependent kinase inhibitor 1B; targeted mutation 3, Matthew L Fero
• MGI ID: MGI:3623441
• Synonyms: p27^S-, p27stop
• Gene: Cdkn1b Location: Chr6:134897364-134902476 bp, + strand Genetic Position: Chr6, 65.77 cM
• Alliance: Cdkn1b^tm3Mlf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107588
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed transcriptional stop cassette was inserted into the 5' UTR. Protein was nearly undetectable in mutants. (J:107588)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn1b Mutation: 26 strains or lines available

References

• Original: J:107588 Chien WM, et al., Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4122-7
• All: 1 reference(s)