Prokr2^tm1Api
Targeted Allele Detail

Summary

• Symbol: Prokr2^tm1Api
• Name: prokineticin receptor 2; targeted mutation 1, Shunichiro Matsumoto
• MGI ID: MGI:3623447
• Synonyms: Pkr2^-
• Gene: Prokr2 Location: Chr2:132211625-132227413 bp, - strand Genetic Position: Chr2, 64.15 cM
• Alliance: Prokr2^tm1Api page

Prokr2^tm1Api/Prokr2^tm1Api mice, but not Prokr1^tm1Api/Prokr1^tm1Api mice, display olfactory bulb malformation

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107587
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An exon containing the ATG start codon was deleted and a neo cassette in reverse orientation was inserted. Quantitative PCR confirmed ablation of the locus. (J:107587)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prokr2 Mutation: 43 strains or lines available

References

• Original: J:107587 Matsumoto S, et al., Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4140-5
• All: 1 reference(s)