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Gria2tm2Rlh
Targeted Allele Detail
Summary
Symbol: Gria2tm2Rlh
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 2, Richard L Huganir
MGI ID: MGI:3623451
Synonyms: GluR2 K882A
Gene: Gria2  Location: Chr3:80588757-80710142 bp, - strand  Genetic Position: Chr3, 35.5 cM
Alliance: Gria2tm2Rlh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107573
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA targeting vector was designed to insert a floxed neo into the locus as well as the K882A substitution into the exon encoding transmembrane domain 4 and the C terminus region. The neo was subsequently removed via cre recombinase expression. A reduction in the levels of the long isoform was found particularly in mutants of 1 month of age. (J:107573)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria2 Mutation:  79 strains or lines available
References
Original:  J:107573 Steinberg JP, et al., Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression. Neuron. 2006 Mar 16;49(6):845-60
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory