Gria2^tm2Rlh
Targeted Allele Detail

Summary

• Symbol: Gria2^tm2Rlh
• Name: glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 2, Richard L Huganir
• MGI ID: MGI:3623451
• Synonyms: GluR2 K882A
• Gene: Gria2 Location: Chr3:80588757-80710142 bp, - strand Genetic Position: Chr3, 35.5 cM
• Alliance: Gria2^tm2Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107573
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert a floxed neo into the locus as well as the K882A substitution into the exon encoding transmembrane domain 4 and the C terminus region. The neo was subsequently removed via cre recombinase expression. A reduction in the levels of the long isoform was found particularly in mutants of 1 month of age. (J:107573)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gria2 Mutation: 79 strains or lines available

References

• Original: J:107573 Steinberg JP, et al., Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression. Neuron. 2006 Mar 16;49(6):845-60
• All: 5 reference(s)