Slc26a6^tm1Psar
Targeted Allele Detail

Summary

• Symbol: Slc26a6^tm1Psar
• Name: solute carrier family 26, member 6; targeted mutation 1, Peter S Aronson
• MGI ID: MGI:3623454
• Synonyms: Slc26a6^-
• Gene: Slc26a6 Location: Chr9:108731239-108742117 bp, + strand Genetic Position: Chr9, 59.63 cM, cytoband F2
• Alliance: Slc26a6^tm1Psar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107558
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to disrupt the locus by replacing parts of exons 2 and 5 and all of exons 3 and 4 with a neomycin resistance cassette. Northern blot of mutant kidney confirmed absence of the major 2.7 kb transcript. Immunoblot confirmed absence of protein in mutants. (J:107558)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc26a6 Mutation: 33 strains or lines available

References

• Original: J:107558 Jiang Z, et al., Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nat Genet. 2006 Apr;38(4):474-8
• All: 7 reference(s)