Adipoq^tm1Pesch
Targeted Allele Detail

Summary

• Symbol: Adipoq^tm1Pesch
• Name: adiponectin, C1Q and collagen domain containing; targeted mutation 1, Philipp E Scherer
• MGI ID: MGI:3623488
• Synonyms: Adipoq^tm1Pesc
• Gene: Adipoq Location: Chr16:22965286-22976718 bp, + strand Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
• Alliance: Adipoq^tm1Pesch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107486
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 1, exon 2 and the coding part of exon 3 with a neomycin resistance gene. Western blot failed to detect protein in mutants. (J:107486)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adipoq Mutation: 40 strains or lines available

References

• Original: J:107486 Nawrocki AR, et al., Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem. 2006 Feb 3;281(5):2654-60
• All: 33 reference(s)