Ptgs2^tm1Hahe
Targeted Allele Detail

Summary

• Symbol: Ptgs2^tm1Hahe
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1, Harvey R Herschman
• MGI ID: MGI:3623499
• Synonyms: Cox-2^flox, Ptgs2^tm1Hrh
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^tm1Hahe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107615
• Parent Cell Line: LW1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exons 4 and 5 with loxP sites. Deletion of these exons would cause a frame shift, resulting in a stop codon after eight missense amino acids in exon 6. (J:107615)

Expression

In Mice Carrying this Mutation:

2 assay results 1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptgs2^tm1Hahe

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 73 strains or lines available

References

• Original: J:107615 Ishikawa TO, et al., Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 (Cox-2) gene. Genesis. 2006 Mar;44(3):143-9
• All: 34 reference(s)