Reck^tm1Ito
Targeted Allele Detail

Summary

• Symbol: Reck^tm1Ito
• Name: reversion-inducing-cysteine-rich protein with kazal motifs; targeted mutation 1, Shigeyoshi Itohara
• MGI ID: MGI:3623517
• Synonyms: Reck^-
• Gene: Reck Location: Chr4:43875530-43944806 bp, + strand Genetic Position: Chr4, 23.05 cM
• Alliance: Reck^tm1Ito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107674
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 1 with a PGK-neo cassette. Northern and Western blot analyses confirmed absence of transcript and protein, respectively. (J:107674)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Reck Mutation: 46 strains or lines available

References

• Original: J:107674 Oh J, et al., The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell. 2001 Dec 14;107(6):789-800
• All: 8 reference(s)