Rtn4^tm1Schw
Targeted Allele Detail

Summary

• Symbol: Rtn4^tm1Schw
• Name: reticulon 4; targeted mutation 1, Martin E Schwab
• MGI ID: MGI:3623522
• Synonyms: Nogo^-, Nogo-A^-, nogo-a^EIII, NogoA KO
• Gene: Rtn4 Location: Chr11:29642947-29694331 bp, + strand Genetic Position: Chr11, 16.79 cM
• Alliance: Rtn4^tm1Schw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107700
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced parts of exons 2 and 3. Isoform A was not detectable in tissues of mutants. Protein from isoform A was not detected by immunoblot analysis. (J:107700)

Expression

In Mice Carrying this Mutation:	29 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rtn4 Mutation: 131 strains or lines available

References

• Original: J:107700 Simonen M, et al., Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron. 2003 Apr 24;38(2):201-11
• All: 27 reference(s)