Grik2^tm1Bvis
Targeted Allele Detail

Summary

• Symbol: Grik2^tm1Bvis
• Name: glutamate receptor, ionotropic, kainate 2 (beta 2); targeted mutation 1, B Vissel
• MGI ID: MGI:3623590
• Synonyms: ECSdelta
• Gene: Grik2 Location: Chr10:48970929-49664862 bp, - strand Genetic Position: Chr10, 24.87 cM
• Alliance: Grik2^tm1Bvis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107698
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to remove the editing complementary site by replacement with a floxed neomysin resistance gene, and subsequent removal of that gene. An editing assay confirmed that editing was essentially abolished in mutant mice. (J:107698)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grik2 Mutation: 65 strains or lines available

References

• Original: J:107698 Vissel B, et al., The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron. 2001 Jan;29(1):217-27
• All: 4 reference(s)