Del(18Pcdhg)1Xzw
Targeted Allele Detail

Summary

• Symbol: Del(18Pcdhg)1Xzw
• Name: deletion, Chr 18, Xiaozhong Wang 1
• MGI ID: MGI:3623611
• Synonyms: Del(18Pcdhga1-Pcdhgc3)1Jrs, Del1Jrs, Pcdh-g^del
• Gene: Del(18Pcdhg)1Xzw Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107735
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: Cre mediated recombination resulted in the deletion of the protocadherin gamma locus extending from subfamily A, 1 to the third common exon. Northern blot using a probe for the protocadherin gamma common exons confirmed the complete loss of transcript in mutants. Absence of protein was confirmed by Western blot analysis. (J:107735)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(18Pcdhg)1Xzw Mutation: 0 strains or lines available

References

• Original: J:107735 Wang X, et al., Gamma protocadherins are required for survival of spinal interneurons. Neuron. 2002 Dec 5;36(5):843-54
• All: 7 reference(s)