Ackr2^tm1Gjg
Targeted Allele Detail

Summary

• Symbol: Ackr2^tm1Gjg
• Name: atypical chemokine receptor 2; targeted mutation 1, Gerard J Graham
• MGI ID: MGI:3623613
• Synonyms: D6^-
• Gene: Ackr2 Location: Chr9:121727421-121740140 bp, + strand Genetic Position: Chr9, 72.71 cM, cytoband F4
• Alliance: Ackr2^tm1Gjg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97607
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace the entire coding sequence with a neomycin resistance gene. Northern blot showed the loss of transcript in mutant lung samples. (J:97607)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ackr2 Mutation: 24 strains or lines available

References

• Original: J:97607 Jamieson T, et al., The chemokine receptor D6 limits the inflammatory response in vivo. Nat Immunol. 2005 Apr;6(4):403-11
• All: 35 reference(s)