Mapk7^tm1Jsca
Targeted Allele Detail

Summary

• Symbol: Mapk7^tm1Jsca
• Name: mitogen-activated protein kinase 7; targeted mutation 1, J Simon C Arthur
• MGI ID: MGI:3623627
• Synonyms: Erk5^-
• Gene: Mapk7 Location: Chr11:61379638-61385101 bp, - strand Genetic Position: Chr11, 37.96 cM
• Alliance: Mapk7^tm1Jsca page

Morphology of wild type and Mapk7^tm1Jsca/Mapk7^tm1Jsca yolk sacs

Show the 8 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107620
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 4 and 5 of the locus with a neomycin resistance gene. Immunoblot demonstrated that protein was absent from mutants. There was no evidence of truncated protein production. (J:107620)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk7 Mutation: 32 strains or lines available

References

• Original: J:107620 Yan L, et al., Knockout of ERK5 causes multiple defects in placental and embryonic development. BMC Dev Biol. 2003 Dec 16;3:11
• All: 1 reference(s)