Kif2a^tm1Noh
Targeted Allele Detail

Summary

• Symbol: Kif2a^tm1Noh
• Name: kinesin family member 2A; targeted mutation 1, Nobutaka Hirokawa
• MGI ID: MGI:3623680
• Synonyms: Kif2a^-, Kif2a^{Gt(Betageo)1Noh}
• Gene: Kif2a Location: Chr13:107095504-107158634 bp, - strand Genetic Position: Chr13, 58.06 cM, cytoband F
• Alliance: Kif2a^tm1Noh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107737
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A betageo replaced 0.9 kb coding region of the ATP binding consensus P loop of the motor domain by a promoter gene trap strategy. The vector was designed to create a frame shift and also disrupt the beta splicing isoform. Western blot confirmed ablation of protein. (J:107737)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif2a Mutation: 27 strains or lines available

References

• Original: J:107737 Homma N, et al., Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Cell. 2003 Jul 25;114(2):229-39
• All: 4 reference(s)