Dnah11^tm1Bknr
Targeted Allele Detail

Summary

• Symbol: Dnah11^tm1Bknr
• Name: dynein, axonemal, heavy chain 11; targeted mutation 1, Martina Brueckner
• MGI ID: MGI:3623682
• Synonyms: Lrd^GFPdeltaneo
• Gene: Dnah11 Location: Chr12:117841717-118162778 bp, - strand Genetic Position: Chr12, 63.25 cM
• Alliance: Dnah11^tm1Bknr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107740
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was used to insert a GFP immediately downstream of the ATG in exon 1. A floxed neomycin resistance gene was included in the vector. Aberrant splicing resulted in failure in expression of GFP or full length endogenous transcripts. (J:107740)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnah11 Mutation: 217 strains or lines available

References

• Original: J:107740 McGrath J, et al., Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell. 2003 Jul 11;114(1):61-73
• All: 4 reference(s)