Dync2h1^{Gt(RRM278)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Dync2h1^{Gt(RRM278)Byg}
• Name: dynein cytoplasmic 2 heavy chain 1; gene trap RRM278, BayGenomics
• MGI ID: MGI:3623884
• Synonyms: Dnchc2^GT, Dync2h1^{Gt(pGToLxf)1Byg}
• Gene: Dync2h1 Location: Chr9:6928550-7177619 bp, - strand Genetic Position: Chr9, Syntenic
• Alliance: Dync2h1^{Gt(RRM278)Byg} page

Mutation origin

• Mutant Cell Line: RRM278
• Germline Transmission: Earliest citation of germline transmission: J:100466
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The insertion of a gene trap vector, pGT0Lxf, resulted in the fusion of a beta-geo to the N-terminal 734 amino acids. (J:100466)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRM278	CG672088 ; (MGI Seq Detail)	5' RACE	Chr9:7158831-7162780 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  2 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dync2h1 Mutation: 215 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:100466 Huangfu D, et al., Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11325-30
• All: 3 reference(s)