Lingo1^tm1Shmi
Targeted Allele Detail

Summary

• Symbol: Lingo1^tm1Shmi
• Name: leucine rich repeat and Ig domain containing 1; targeted mutation 1, Sha Mi
• MGI ID: MGI:3623893
• Gene: Lingo1 Location: Chr9:56525759-56703752 bp, - strand Genetic Position: Chr9, 30.28 cM, cytoband A3
• Alliance: Lingo1^tm1Shmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99078
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A GFP-neo replaced the entire single-exon coding sequence. Northern blot failed to detect transcript in mutant mice. (J:99078)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lingo1 Mutation: 33 strains or lines available

References

• Original: J:99078 Mi S, et al., LINGO-1 negatively regulates myelination by oligodendrocytes. Nat Neurosci. 2005 Jun;8(6):745-51
• All: 5 reference(s)