Prdm9^tm1Ymat
Targeted Allele Detail

Summary

• Symbol: Prdm9^tm1Ymat
• Name: PR domain containing 9; targeted mutation 1, Yasuhisa Matsui
• MGI ID: MGI:3623909
• Synonyms: Meisetz^-
• Gene: Prdm9 Location: Chr17:15763341-15784616 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Prdm9^tm1Ymat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102875
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing the lacZ gene and a loxP-flanked PGKneo cassette disrupted part of exon 2, which contains the initiation codon, all of exons 3 to 6, and part of exon 7. RT-PCR analysis of testes from homozygous mutant mice did not detect transcript. (J:102875)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Prdm9 Mutation: 46 strains or lines available

References

• Original: J:102875 Hayashi K, et al., A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Nature. 2005 Nov 17;438(7066):374-8
• All: 27 reference(s)