Pttg1^tm1.1Tno
Targeted Allele Detail

Summary

• Symbol: Pttg1^tm1.1Tno
• Name: pituitary tumor-transforming gene 1; targeted mutation 1.1, Tetsuo Noda
• MGI ID: MGI:3624005
• Synonyms: Securin^null
• Gene: Pttg1 Location: Chr11:43311077-43317078 bp, - strand Genetic Position: Chr11, 25.68 cM
• Alliance: Pttg1^tm1.1Tno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107917
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted upstream of exon 2, and a loxP site was inserted downstream of exon 2. Cre mediated recombination removed exon 2 and the neo cassette. (J:107917)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pttg1 Mutation: 16 strains or lines available

References

• Original: J:107917 Kumada K, et al., The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase. J Cell Biol. 2006 Mar 13;172(6):835-46
• All: 1 reference(s)