Tg(Afp-IGFBP1)2Csw
Transgene Detail

Summary

• Symbol: Tg(Afp-IGFBP1)2Csw
• Name: transgene insertion 2, Carole Watson
• MGI ID: MGI:3624007
• Transgene: Tg(Afp-IGFBP1)2Csw Location: unknown
• Alliance: Tg(Afp-IGFBP1)2Csw page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Afp-IGFBP1)2Csw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGFBP1 (3484)

  Igfbp1

  (MGI:96436)

• Mutation details: A 9.2kb transgene containing the human IGFBP1 cDNA under the control of the mouse alpha-fetoprotein regulatory sequence was microinjected into the pronuclei of C57BL/6 x CBA F1 embryos. Four founder lines were established (2,3,4,16). Line 2 contains 4 copies of the transgene and expresses at high levels in fetal liver and yolk sac with lower levels of expression in gut epithelial cells and brain glial cells. (J:108414)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:108414 Watson CS, et al., Elevated circulating insulin-like growth factor binding protein-1 is sufficient to cause fetal growth restriction. Endocrinology. 2006 Mar;147(3):1175-86
• All: 1 reference(s)