Hipk1^tm1Hko
Targeted Allele Detail

Summary

• Symbol: Hipk1^tm1Hko
• Name: homeodomain interacting protein kinase 1; targeted mutation 1, Haruhiko Koseki
• MGI ID: MGI:3624126
• Synonyms: Hipk1^-
• Gene: Hipk1 Location: Chr3:103647131-103698879 bp, - strand Genetic Position: Chr3, 45.52 cM, cytoband F3
• Alliance: Hipk1^tm1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace sequence including the start codon with a neomycin resistance gene. RT-PCR demonstrated a lack of transcript in mutants, but absence of C-terminally truncated proteins could not be concluded. (J:106931)

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hipk1 Mutation: 61 strains or lines available

References

• Original: J:106931 Isono K, et al., Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol. 2006 Apr;26(7):2758-71
• All: 3 reference(s)