Hipk2^tm1Hko
Targeted Allele Detail

Summary

• Symbol: Hipk2^tm1Hko
• Name: homeodomain interacting protein kinase 2; targeted mutation 1, Haruhiko Koseki
• MGI ID: MGI:3624127
• Synonyms: Hipk2^-
• Gene: Hipk2 Location: Chr6:38671325-38853099 bp, - strand Genetic Position: Chr6, 17.85 cM, cytoband B
• Alliance: Hipk2^tm1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace sequence containing the start codon and the flanking intronic region with the neomycin resistance gene. RT-PCR demonstrated a lack of transcript in mutants. Western blot showed no wild-type protein, but absence of C-terminally truncated proteins could not be concluded. (J:106931)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hipk2 Mutation: 55 strains or lines available

References

• Original: J:106931 Isono K, et al., Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol. 2006 Apr;26(7):2758-71
• All: 5 reference(s)