Espl1^tm1.1Kna
Targeted Allele Detail

Summary

• Symbol: Espl1^tm1.1Kna
• Name: extra spindle pole bodies 1, separase; targeted mutation 1.1, Kim Nasmyth
• MGI ID: MGI:3624200
• Synonyms: Separase^flox
• Gene: Espl1 Location: Chr15:102204701-102232792 bp, + strand Genetic Position: Chr15, 57.45 cM
• Alliance: Espl1^tm1.1Kna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107916
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was used to flank the 8 COOH terminal exons with loxP sites. This sequence encoded the catalytic dyad. (J:107916)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Espl1 Mutation: 95 strains or lines available

References

• Original: J:107916 Wirth KG, et al., Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J Cell Biol. 2006 Mar 13;172(6):847-60
• All: 7 reference(s)