Smad4^tm1.1Rob
Targeted Allele Detail

Summary

• Symbol: Smad4^tm1.1Rob
• Name: SMAD family member 4; targeted mutation 1.1, Elizabeth J Robertson
• MGI ID: MGI:3624263
• Synonyms: Smad4^-, Smad4^N, Smad4^RobN
• Gene: Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
• Alliance: Smad4^tm1.1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92066
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1 was removed via transient cre expression in ES cells. Western blot analysis shows that the predominant wild-type protein was absent in mutant ES cells. (J:92066)

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad4 Mutation: 48 strains or lines available

References

• Original: J:92066 Chu GC, et al., Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development. 2004 Aug;131(15):3501-12
• All: 8 reference(s)