Trp53^tm3Wahl
Targeted Allele Detail

Summary

• Symbol: Trp53^tm3Wahl
• Name: transformation related protein 53; targeted mutation 3, Geoffrey M Wahl
• MGI ID: MGI:3624429
• Synonyms: p53^deltaP
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm3Wahl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108183
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting construct was used to remove sequence coding for six prolines and both PXXP motifs (p.E75_S91del). Quantification of mRNAs from mutant and wild-type demonstrated identical transcription from both alleles. (J:108183)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm3Wahl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:108183 Toledo F, et al., A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell. 2006 Apr;9(4):273-85
• All: 5 reference(s)