Rb1^tm1.2Gfk
Targeted Allele Detail

Summary

• Symbol: Rb1^tm1.2Gfk
• Name: RB transcriptional corepressor 1; targeted mutation 1.2, Graham F Kay
• MGI ID: MGI:3624441
• Synonyms: Rb1^deltaX2
• Gene: Rb1 Location: Chr14:73430298-73563446 bp, - strand Genetic Position: Chr14, 38.73 cM, cytoband D3
• Alliance: Rb1^tm1.2Gfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108628
• Parent Cell Line: C1368 (ES Cell)
• Strain of Origin: 129T2/SvEms

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette flanked by FRT sites and with a 5' loxP site was inserted in intron 1. An additional loxP site was also inserted in intron 2. The neomycin cassette was subsequently excised by crossing with flpe-deleter mice. Exon 2 was then removed by crossing with Tg(CMV-cre)1Cgn mice. (J:108628)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rb1^tm1.2Gfk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rb1 Mutation: 111 strains or lines available

References

• Original: J:108628 Tonks ID, et al., Melanocytes in conditional Rb-/- mice are normal in vivo but exhibit proliferation and pigmentation defects in vitro. Pigment Cell Res. 2005 Aug;18(4):252-64
• All: 4 reference(s)