Igh^tm2Emo
Targeted Allele Detail

Summary

• Symbol: Igh^tm2Emo
• Name: immunoglobulin heavy chain complex; targeted mutation 2, Eugene M Oltz
• MGI ID: MGI:3624531
• Synonyms: P^-E^-
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108098
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Deletion
• Igh^tm2Emo involves 1 genes/genome features (Igh) View all
• Mutation details: A targeting vector was constructed to remove the PDQ52 sequence as well as the Emu and its 5' matrix attachment region (MAR). (J:108098)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:108098 Afshar R, et al., Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination. J Immunol. 2006 Feb 15;176(4):2439-47
• All: 4 reference(s)