Dcx^tm1.2Ffr
Targeted Allele Detail

Summary

• Symbol: Dcx^tm1.2Ffr
• Name: doublecortin; targeted mutation 1.2, Fiona Francis
• MGI ID: MGI:3624537
• Gene: Dcx Location: ChrX:142638838-142716307 bp, - strand Genetic Position: ChrX, 64.89 cM
• Alliance: Dcx^tm1.2Ffr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108229
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was removed via homologous recombination. Western blot confirmed absence of protein in mutants. (J:108229)

Disease models

Expression

In Mice Carrying this Mutation:	63 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dcx Mutation: 20 strains or lines available

References

• Original: J:108229 Kappeler C, et al., Branching and nucleokinesis defects in migrating interneurons derived from doublecortin knockout mice. Hum Mol Genet. 2006 May 1;15(9):1387-400
• All: 11 reference(s)