Coch^tm1.1Stw
Targeted Allele Detail

Summary

• Symbol: Coch^tm1.1Stw
• Name: cochlin; targeted mutation 1.1, Colin L Stewart
• MGI ID: MGI:3624560
• Synonyms: Coch^-
• Gene: Coch Location: Chr12:51640156-51652558 bp, + strand Genetic Position: Chr12, 22.11 cM
• Alliance: Coch^tm1.1Stw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105566
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 7-11 and part of exon 12, encoding the two vWA domains and remaining cochlin protein downstream of the LCCL domain, were removed via cre mediated recombination. Neither full length or truncated transcripts were detected in mutants. (J:105566)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Coch Mutation: 43 strains or lines available

References

• Original: J:105566 Rodriguez CI, et al., Cochlin, a secreted von Willebrand factor type a domain-containing factor, is regulated by leukemia inhibitory factor in the uterus at the time of embryo implantation. Endocrinology. 2004 Mar;145(3):1410-8
• All: 11 reference(s)