H6pd^tm1Pmst
Targeted Allele Detail

Summary

• Symbol: H6pd^tm1Pmst
• Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); targeted mutation 1, Paul M Stewart
• MGI ID: MGI:3624665
• Gene: H6pd Location: Chr4:150063932-150093480 bp, - strand Genetic Position: Chr4, 80.65 cM
• Alliance: H6pd^tm1Pmst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108281
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced by a neomycin resistance gene. Absence of protein was confirmed by immunoblot of mutant liver microsomes. (J:108281)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H6pd Mutation: 60 strains or lines available

References

• Original: J:108281 Lavery GG, et al., Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation. J Biol Chem. 2006 Mar 10;281(10):6546-51
• All: 9 reference(s)