Mpp4^tm1Wij
Targeted Allele Detail

Summary

• Symbol: Mpp4^tm1Wij
• Name: membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4); targeted mutation 1, Jan Wijnholds
• MGI ID: MGI:3624689
• Synonyms: Mpp4^-
• Gene: Mpp4 Location: Chr1:59160094-59202548 bp, - strand Genetic Position: Chr1, 29.2 cM
• Alliance: Mpp4^tm1Wij page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108232
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct containing a PGK-neo was inserted to replace intron 7 and 123 bp of exons 7 and 8, resulting in the generation of a frame shift in the 5' part of exon 7 encoding the PDZ domain of the protein. (J:108232)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpp4 Mutation: 42 strains or lines available

References

• Original: J:108232 Aartsen WM, et al., Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse. Hum Mol Genet. 2006 Apr 15;15(8):1291-302
• All: 2 reference(s)