Aqp2^tm1Nlsn
Targeted Allele Detail

Summary

• Symbol: Aqp2^tm1Nlsn
• Name: aquaporin 2; targeted mutation 1, Soren Nielsen
• MGI ID: MGI:3624696
• Synonyms: Aqp2^flx
• Gene: Aqp2 Location: Chr15:99476937-99482426 bp, + strand Genetic Position: Chr15, 56.13 cM
• Alliance: Aqp2^tm1Nlsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108291
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted into introns 2 and 3. (J:108291)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aqp2 Mutation: 17 strains or lines available

References

• Original: J:108291 Rojek A, et al., Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):6037-42
• All: 3 reference(s)