Scgq4^C57BL/6Slc
QTL Variant Detail

Summary

• QTL variant: Scgq4^C57BL/6Slc
• Name: spontaneous crescentic glomerulonephritis QTL 4; C57BL/6Slc
• MGI ID: MGI:3624767
• QTL: Scgq4 Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 17.26 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: C57BL/6Slc

Variant description

• Allele Type: QTL
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:108420

Linkage analysis was performed on 420 female animals from a (C57BL/6Slc x SCG/Knj)F2 intercross to identify QTL for renal phenotypes. Parental strain SCG/Knj is derived from BXSB/Mp and MRL/Mp-Fas^lpr, and spontaneously develops crescentic glomerulonephritis and vascularitis. The Fas-^lpr mutation is largely responsible for the disease phenotype but this experiment seeks to identify non-Fas disease-associated loci. 102 polymorphic markers covering 85% of the genome at a 20 cM resolution was used for the genome scan. F2 animals were analyzed by cohorts grouped according to genotype at the Fas locus.

Scgq4 (spontaneous crescentic glomerulonephritis QTL 4) maps to mouse Chromosome 7 near D7Mit117 (11 cM) and D7Mit80 (18 cM) with LOD=5.4 for total serum IgM at 12 weeks of age. SCG/Knj-derived alleles at Scgq4 confer increased IgM with a recessive mode of inheritance. This locus accounts for 11% of the phenotypic variance. Previously identified renal QTL mapping near Scgq4 include Sle3 (15 cM), Lbw5 (23 cM),Nba5 (23 cM), and Lmb3 (28 cM). Cd22 (9 cM) and Bax (23 cM) are possible candidate genes for Scgq4.

References

• Original: J:108420 Hamano Y, et al., Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice. J Immunol. 2006 Mar 15;176(6):3662-73
• All: 1 reference(s)