Bfsp2^tm1Pgf
Targeted Allele Detail

Summary

• Symbol: Bfsp2^tm1Pgf
• Name: beaded filament structural protein 2, phakinin; targeted mutation 1, Paul G FitzGerald
• MGI ID: MGI:3624777
• Synonyms: CP49^-, phakosin^ko
• Gene: Bfsp2 Location: Chr9:103302123-103357608 bp, - strand Genetic Position: Chr9, 55.37 cM
• Alliance: Bfsp2^tm1Pgf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108387
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1. RT-PCR confirmed absence of the exon and presence of the neo. Northern blot did not detect transcripts in mutants. (J:108387)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bfsp2 Mutation: 29 strains or lines available

References

• Original: J:108387 Alizadeh A, et al., Targeted genomic deletion of the lens-specific intermediate filament protein CP49. Invest Ophthalmol Vis Sci. 2002 Dec;43(12):3722-7
• All: 3 reference(s)