Nle1^tm1Cba
Targeted Allele Detail

Summary

• Symbol: Nle1^tm1Cba
• Name: notchless homolog 1; targeted mutation 1, Charles Babinet
• MGI ID: MGI:3624778
• Synonyms: mNl1^-, Nle^null
• Gene: Nle1 Location: Chr11:82791594-82799237 bp, - strand Genetic Position: Chr11, 50.3 cM
• Alliance: Nle1^tm1Cba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108385
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An NLS-LacZ construct was inserted in frame to replace exons 2 and 3. The first six amino acids of the endogenous protein fused to beta-galactosidase. (J:108385)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nle1 Mutation: 27 strains or lines available

References

• Original: J:108385 Cormier S, et al., The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells. Mol Cell Biol. 2006 May;26(9):3541-9
• All: 5 reference(s)