Itgb1^tm3Mlkn
Targeted Allele Detail

Summary

• Symbol: Itgb1^tm3Mlkn
• Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 3, Mark L Kahn
• MGI ID: MGI:3624806
• Gene: Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
• Alliance: Itgb1^tm3Mlkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108331
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites flanking exon 15. Coding sequence for a mutant exon 15 containing Y783A and Y795A substitutions was inserted such that cre mediated excision of the endogenous exon 15 would allow expression of the mutant exon. (J:108331)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb1 Mutation: 60 strains or lines available

References

• Original: J:108331 Chen H, et al., In vivo beta1 integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines. Genes Dev. 2006 Apr 15;20(8):927-32
• All: 1 reference(s)