Htr2a^tm1Rhn
Targeted Allele Detail

Summary

• Symbol: Htr2a^tm1Rhn
• Name: 5-hydroxytryptamine (serotonin) receptor 2A; targeted mutation 1, Rene Hen
• MGI ID: MGI:3624812
• Synonyms: 2AR-KO, 5-HT2a^-
• Gene: Htr2a Location: Chr14:74878314-74944299 bp, + strand Genetic Position: Chr14, 39.37 cM
• Alliance: Htr2a^tm1Rhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108763
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A floxed neo-stop cassette was placed between the promoter and the coding sequence. (J:108763, J:122935)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr2a Mutation: 43 strains or lines available

References

• Original: J:108763 Gingrich JA, et al., Targeted Disruption of the 5-HT 2A Receptor Gene in Transgenic Mice. Neuroscience. 1998;24:773 (Abstract 308.10)
• All: 17 reference(s)