Ptprn^tm1Aln
Targeted Allele Detail

Summary

• Symbol: Ptprn^tm1Aln
• Name: protein tyrosine phosphatase receptor type N; targeted mutation 1, Abner Louis Notkins
• MGI ID: MGI:3625093
• Synonyms: IA-2^-
• Gene: Ptprn Location: Chr1:75223671-75241146 bp, - strand Genetic Position: Chr1, 38.64 cM
• Alliance: Ptprn^tm1Aln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108765
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace sequence spanning from the 5' upstream promoter region to intron 3 with a neomycin resistance gene. Western blot failed to detect protein in mutant brain extract. (J:108765)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprn Mutation: 38 strains or lines available

References

• Original: J:108765 Saeki K, et al., Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion. Diabetes. 2002 Jun;51(6):1842-50
• All: 13 reference(s)