Ids^tm1Muen
Targeted Allele Detail

Summary

• Symbol: Ids^tm1Muen
• Name: iduronate 2-sulfatase; targeted mutation 1, Joseph Muenzer
• MGI ID: MGI:3625122
• Synonyms: ids^-, MPSII
• Gene: Ids Location: ChrX:69386675-69408690 bp, - strand Genetic Position: ChrX, 36.01 cM
• Alliance: Ids^tm1Muen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108761
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A targeting vector was designed to replace exon 4 and part of 5 with a neomycin resistance gene. (J:108761)

Disease models

Expression

In Structures Affected by this Mutation:

30 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ids Mutation: 11 strains or lines available

References

• Original: J:108761 Muenzer J, et al., Enzyme replacement therapy in mucopolysaccharidosis type II (Hunter syndrome): a preliminary report. Acta Paediatr Suppl. 2002;91(439):98-9
• All: 16 reference(s)