Trat1^tm1Lsmn
Targeted Allele Detail

Summary

• Symbol: Trat1^tm1Lsmn
• Name: T cell receptor associated transmembrane adaptor 1; targeted mutation 1, Luca Simeoni
• MGI ID: MGI:3625134
• Synonyms: TRIM^-
• Gene: Trat1 Location: Chr16:48551137-48592384 bp, - strand Genetic Position: Chr16, 30.75 cM
• Alliance: Trat1^tm1Lsmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108406
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 and exon 2, sequence encompassing the ATG and the entire transmembrane region, were replaced with a neomycin cassette. Western blot failed to detect protein in mutant thymocytes. (J:108406)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trat1 Mutation: 17 strains or lines available

References

• Original: J:108406 Kolsch U, et al., Normal T-cell development and immune functions in TRIM-deficient mice. Mol Cell Biol. 2006 May;26(9):3639-48
• All: 2 reference(s)