Sox2^tm4Lpev
Targeted Allele Detail

Summary

• Symbol: Sox2^tm4Lpev
• Name: SRY (sex determining region Y)-box 2; targeted mutation 4, Larysa H Pevny
• MGI ID: MGI:3625178
• Synonyms: Sox2^IR
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^tm4Lpev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108452
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed so that the 3' UTR of the locus was replaced by an IRES and dsRED2 coding sequence followed by a floxed neomycin cassette. This allele is a hypomorph. (J:108452)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:108452 Taranova OV, et al., SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev. 2006 May 1;20(9):1187-202
• All: 3 reference(s)