Adora2a^tm1.1Dyj
Targeted Allele Detail

Summary

• Symbol: Adora2a^tm1.1Dyj
• Name: adenosine A2a receptor; targeted mutation 1.1, Yuan-Ji Day
• MGI ID: MGI:3625456
• Synonyms: A2A-, Adora2a^tm1.1Masc
• Gene: Adora2a Location: Chr10:75152711-75170618 bp, + strand Genetic Position: Chr10, 38.52 cM, cytoband B5.3
• Alliance: Adora2a^tm1.1Dyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104338
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Variable germline expression of cre disrupted the targeted allele carrying floxed exon 2 resulting in removal of exon 2 in some gonadal cells, instead of the expected tissue-specific disruption of the floxed allele by the Camk2a-cre transgene. (J:104338)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adora2a Mutation: 40 strains or lines available

References

• Original: J:104338 Bastia E, et al., A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitization. Neuropsychopharmacology. 2005 May;30(5):891-900
• All: 7 reference(s)