Dppa5a^tm1Yam
Targeted Allele Detail

Summary

• Symbol: Dppa5a^tm1Yam
• Name: developmental pluripotency associated 5A; targeted mutation 1, Shinya Yamanaka
• MGI ID: MGI:3625479
• Synonyms: Esg1^-
• Gene: Dppa5a Location: Chr9:78274334-78275459 bp, - strand Genetic Position: Chr9, 43.65 cM
• Alliance: Dppa5a^tm1Yam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107238
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination was used to replace the entire coding sequence with either a vector containing an IRES-Betageo cassette or an IRES-HygR cassette constructed by a previous promoter trap selection in a BAC. Northern blot and Western blot confirmed absence of transcript and protein, respectively, in mutant ES cells. (J:107238)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dppa5a Mutation: 9 strains or lines available

References

• Original: J:107238 Amano H, et al., Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5). BMC Dev Biol. 2006;6:11
• All: 1 reference(s)