Adam11^tm1Sag
Targeted Allele Detail

Summary

• Symbol: Adam11^tm1Sag
• Name: a disintegrin and metallopeptidase domain 11; targeted mutation 1, Koji Sagane
• MGI ID: MGI:3625523
• Gene: Adam11 Location: Chr11:102652265-102671088 bp, + strand Genetic Position: Chr11, 66.48 cM
• Alliance: Adam11^tm1Sag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107127
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 6 and part of exons 5 and 7 with a neomycin resistance gene. A termination was introduced into exon 5 in the pro-protein domain as a result, and any protein synthesized from this allele would be truncated and non-functional. Absence of protein in mutant cerebellum was confirmed by Western blot analysis. (J:107127)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adam11 Mutation: 38 strains or lines available

References

• Original: J:107127 Takahashi E, et al., Deficits in spatial learning and motor coordination in ADAM11-deficient mice. BMC Neurosci. 2006;7:19
• All: 2 reference(s)