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Adam11tm1Sag
Targeted Allele Detail
Summary
Symbol: Adam11tm1Sag
Name: a disintegrin and metallopeptidase domain 11; targeted mutation 1, Koji Sagane
MGI ID: MGI:3625523
Gene: Adam11  Location: Chr11:102652265-102671088 bp, + strand  Genetic Position: Chr11, 66.48 cM
Alliance: Adam11tm1Sag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107127
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 6 and part of exons 5 and 7 with a neomycin resistance gene. A termination was introduced into exon 5 in the pro-protein domain as a result, and any protein synthesized from this allele would be truncated and non-functional. Absence of protein in mutant cerebellum was confirmed by Western blot analysis. (J:107127)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam11 Mutation:  38 strains or lines available
References
Original:  J:107127 Takahashi E, et al., Deficits in spatial learning and motor coordination in ADAM11-deficient mice. BMC Neurosci. 2006;7:19
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory