Ddo^tm1Snyd
Targeted Allele Detail

Summary

• Symbol: Ddo^tm1Snyd
• Name: D-aspartate oxidase; targeted mutation 1, Solomon H Snyder
• MGI ID: MGI:3625623
• Synonyms: Ddo^-
• Gene: Ddo Location: Chr10:40506007-40557843 bp, + strand Genetic Position: Chr10, 22.0 cM, cytoband B1
• Alliance: Ddo^tm1Snyd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106267
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neomycin resistance cassette by homologous recombination. The targeting event introduced a frame shift. Northern blot failed to detect transcript in mutant liver and kidney. Western blot confirmed absence of protein, as well. (J:106267)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddo Mutation: 15 strains or lines available

References

• Original: J:106267 Huang AS, et al., D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice. J Neurosci. 2006 Mar 8;26(10):2814-9
• All: 3 reference(s)